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原发性肝鳞状细胞癌少见但有敌意:病例系列和文献综述
Authors Xiao J, Ma L, Li J, Yin B, Liang J, Wang J
Received 11 November 2020
Accepted for publication 8 January 2021
Published 29 January 2021 Volume 2021:13 Pages 829—837
DOI https://doi.org/10.2147/CMAR.S290523
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Ahmet Emre Eşkazan
Abstract: Primary squamous cell carcinoma (SCC) of the liver is an uncommon cancer type. Only dozens of such cases have been reported in the literature. We reviewed three cases with primary SCC of the liver in a single center from January 2013 to October 2019. One case was positive for hepatitis B infection and simultaneously diagnosed with sigmoid adenocarcinoma and liver cyst. The second patient presented with hepatolithiasis. The remaining one had no history of prior liver insult, hepatic infection or any pre-existing hepatic cysts. Two cases had a long survival of more than one year through chemotherapy, or radical surgery plus transarterial chemoembolization. We also found 25 patients with primary hepatic SCC in the Surveillance, Epidemiology and End Results (SEER) database from 1997 to 2016. The median age was 67 years (range 33– 87 years). The median overall survival and disease-specific survival were 7.7 months (range 0.0– 76.0 months) and 2.0 months (range 0.0– 20.0 months), respectively. Furthermore, patients receiving surgery had a longer median OS (20.0 versus 6.0 months, P = 0.016) and DSS (48.0 versus 8.0 months, P = 0.03) than those receiving palliative treatment. Only 20% of all cases survived for more than a year. Although primary SCC of the liver has an unfavorable prognosis, radical surgery and systematic treatment might be helpful for clinical management.
Keywords: primary squamous cell carcinoma, liver, survival, surgery, chemotherapy, SEER