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已发表论文

不同分期胃癌患者转移性淋巴结计数和大小预后价值的初步研究

 

Authors Gao Y, Wang K, Tang XX, Niu JL, Wang J 

Received 3 December 2021

Accepted for publication 13 June 2022

Published 21 June 2022 Volume 2022:14 Pages 2055—2064

DOI https://doi.org/10.2147/CMAR.S352334

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Lu-Zhe Sun

Background: The correlation between the preoperative lymph node count (LNC) on multidetector computed tomography (MDCT) and the prognosis of gastric carcinoma (GC) remains to be defined. This research aims to evaluate the prognostic value of LNC on MDCT in GC patients based on tumor-node-metastasis (TNM) staging, using different size criteria for counting.
Methods: The clinical data of 126 patients with gastric adenocarcinoma undergoing gastrectomy were retrospectively analyzed. Lymph nodes greater than 8mm and 5mm on MDCT were counted and recorded. The prognostic implications of LNC on MDCT for patient survival were analyzed according to different size criteria for counting and tumor TNM staging.
Results: When 8mm was used as the counting criterion, LNC on MDCT had no significant effect on the overall survival (OS) of the entire cohort. In addition, the OS of T1–T2 GC patients with LNC on MDCT ≥ 1 was significantly worse than that of patients with LNC on MDCT < 1. When 5mm was used as the counting criterion, LNC on MDCT was found to be significantly associated with the OS of the entire cohort. In the subgroup analysis, patients with relatively advanced (T3-T4, N+ and III) GC with LNC on MDCT > 7 showed a significantly worse OS than those with LNC on MDCT ≤ 7. LNC on MDCT > 7 with 5mm as the counting criterion and Stage III were independent risk factors for adverse prognosis.
Conclusion: The prognostic value of LNC on MDCT based on different size criteria varies in patients with different stages of GC. LNC of a smaller size (5mm) on MDCT may be a prognostic factor for patients with relatively advanced GC.
Keywords: gastric carcinoma, patient survival, lymph nodes, computed tomography