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已发表论文

围手术期静脉注射利多卡因对回肠造口术后恢复的影响:一项随机对照试验的研究方案

 

Authors Liu J, Liu K, Wang H, Hu H, Sun G, Ye X, Lou Z, Bian J, Bo L

Received 17 February 2022

Accepted for publication 17 June 2022

Published 2 July 2022 Volume 2022:15 Pages 1863—1872

DOI https://doi.org/10.2147/JPR.S362911

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Ellen Soffin

Introduction: Opioids have been widely used clinically as the first choice for pain management. Ileostomy closure usually leads to temporary intestinal paralysis, which manifests as abdominal distension and pain, delayed defecation, nausea, and vomiting. Intraoperative and postoperative use of opioids inhibit gastrointestinal function and aggravate intestinal paralysis, and are notoriously addictive. Thus, reducing perioperative opioid use is important for patients undergoing ileostomy closure to restore the continuity and integrity of the intestine. Intravenous lidocaine has been shown to have anti-inflammatory properties and analgesic effects. We consider minimizing the use of opioids for such patients, and perioperative intravenous injection of lidocaine may be beneficial to the recovery of intestinal function in patients with ileostomy closure.
Methods and Analysis: This is a randomized double-blind placebo-controlled trial to investigate the effectiveness and safety of intravenous lidocaine in patients undergoing ileostomy closure. The time of first postoperative anal venting, postoperative opioids use, postoperative recovery, intraoperative adverse effects and postoperative complications will be collected and analyzed.
Keywords: anesthesia, intravenous, lidocaine, ileostomy, recovery of function