已发表论文

18F-FDG PET-CT 为基础的靶区比较研究和 4DCT 的 10 个阶段用于原发性胸部鳞状食管癌治疗

 

Authors Guo Y, Li J, Zhang P, Zhang Y

Received 28 August 2015

Accepted for publication 9 August 2016

Published 6 January 2017 Volume 2017:10 Pages 177—184

DOI https://doi.org/10.2147/OTT.S95322

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Min Li

Purpose: To investigate the correlations in target volumes based on 18F-FDG PET/CT and four-dimensional CT (4DCT) to detect the feasibility of implementing PET in determining gross target volumes (GTV) for tumor motion for primary thoracic esophageal cancer (EC).
Methods: Thirty-three patients with EC sequentially underwent contrast-enhanced 3DCT, 4DCT, and 
18F-FDG PET-CT thoracic simulation. The internal gross target volume (IGTV)10 was obtained by combining the GTV from ten phases of 4DCT. The GTVs based on PET/CT images were defined by setting of different standardized uptake value thresholds and visual contouring. The difference in volume ratio, conformity index (CI), and degree of inclusion (DI) between IGTV10 and GTVPET was compared.
Results: The images from 20 patients were suitable for further analysis. The optimal volume ratio of 0.95±0.32, 1.06±0.50, 1.07±0.49 was at standardized uptake value (SUV)
2.5, SUV20%, or manual contouring. The mean CIs were from 0.33 to 0.54. The best CI was at SUV2.0 (0.51±0.11), SUV2.5 (0.53±0.13), SUV20% (0.53±0.12), and manual contouring (0.54±0.14). The mean DIs of GTVPET in IGTV10 were from 0.60 to 0.90, and the mean DI of IGTV10 in GTVPET ranged from 0.35 to 0.78. A negative correlation was found between the mean CI and different SUV (=0.000).
Conclusion: None of the PET-based contours had both close spatial and volumetric approximation to the 4DCT IGTV
10. Further evaluation and optimization of PET as a tool for target identification are required.
Keywords: esophageal cancer, 
18F-FDG PET/CT, four-dimensional computed tomography, contour, tumor motion