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Authors Ma K, Gong L, Cai X, Huang P, Cai J, Huang D, Jiang T
Received 21 December 2016
Accepted for publication 3 April 2017
Published 12 May 2017 Volume 2017:12 Pages 3665—3679
DOI https://doi.org/10.2147/IJN.S130857
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Jiang Yang
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Abstract: Implant-associated infections still pose a serious threat leading to
several complications. This study reported an environmentally benign
Ag-containing nanocomposite coating with efficient antibacterial property
fabricated on the metal implant via electrophoretic deposition (EPD). In such
coatings, Ag2O/AgCl mixed with chitosan/gelatin (CS/G) polymers
work together to exert the antibacterial property which could act as an
alternative to traditional Ag nanoparticles. Scanning electron microscopy
images showed the shuttle fiber-like morphology distributed lamellarly and some
nanoparticles carved uniformly into the cross section. Transmission electron
microscopy results revealed a core–shell-like structure of the released
nanoparticles in experimental groups. The Ag-containing coatings exhibited
strong antibacterial properties against Staphylococcus aureus strains and Escherichia coli strains. Meanwhile, the CCK-8 tests
showed that after assembling with chitosan and gelatin polymers, the
cytotoxicity of Ag was largely decreased. In addition, such coatings also
exhibited strong bond strength with metal substrates and good degradable
properties. Therefore, such Ag-containing CS/G coatings fabricated via EPD may
be a promising candidate to be administrated in controlling the
implant-associated infections.
Keywords: infection, green chemistry, chitosan,
gelatin, EPD