已发表论文

一种绿色单步法,用于合成具有低细胞毒性和有效抗菌性能的含 Ag 纳米复合材料涂层

 

Authors Ma K, Gong L, Cai X, Huang P, Cai J, Huang D, Jiang T

Received 21 December 2016

Accepted for publication 3 April 2017

Published 12 May 2017 Volume 2017:12 Pages 3665—3679

DOI https://doi.org/10.2147/IJN.S130857

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Jiang Yang

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun

Abstract: Implant-associated infections still pose a serious threat leading to several complications. This study reported an environmentally benign Ag-containing nanocomposite coating with efficient antibacterial property fabricated on the metal implant via electrophoretic deposition (EPD). In such coatings, Ag2O/AgCl mixed with chitosan/gelatin (CS/G) polymers work together to exert the antibacterial property which could act as an alternative to traditional Ag nanoparticles. Scanning electron microscopy images showed the shuttle fiber-like morphology distributed lamellarly and some nanoparticles carved uniformly into the cross section. Transmission electron microscopy results revealed a core–shell-like structure of the released nanoparticles in experimental groups. The Ag-containing coatings exhibited strong antibacterial properties against Staphylococcus aureus  strains and Escherichia coli  strains. Meanwhile, the CCK-8 tests showed that after assembling with chitosan and gelatin polymers, the cytotoxicity of Ag was largely decreased. In addition, such coatings also exhibited strong bond strength with metal substrates and good degradable properties. Therefore, such Ag-containing CS/G coatings fabricated via EPD may be a promising candidate to be administrated in controlling the implant-associated infections.
Keywords: infection, green chemistry, chitosan, gelatin, EPD