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Authors Gao F, Chen C, Lu J, Zheng J, Ma XC, Yuan XY, Huo K, Han JF
Received 12 April 2017
Accepted for publication 22 May 2017
Published 15 June 2017 Volume 2017:13 Pages 1551—1557
DOI https://doi.org/10.2147/NDT.S139316
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Prof. Dr. Roumen Kirov
Peer reviewer comments 2
Editor who approved publication: Professor Wai Kwong Tang
Purpose: The aspartate transaminase/alanine transaminase ratio (De Ritis ratio,
AAR) was reported to be associated with patients’ prognosis in certain diseases
recently. The objective of the current study was to determine the association
between the AAR at admission and poor outcome at 3 months in acute ischemic
stroke (AIS) patients.
Patients and methods: This retrospective cohort study included patients who
experienced their first-ever AIS between June 2015 and March 2016. The primary
outcome measure was a poor outcome at 3 months (modified Rankin Scale
score >2). Multivariate logistic regression models were used to assess the
relationship between AAR quartiles and clinical outcomes among the AIS
patients. Receiver operating characteristic curve analysis was applied to
identify the optimal cutoff for AAR in predicting the prognosis of AIS.
Results: In terms of the relationship between poor outcome and
AAR, the adjusted odds ratio comparing the highest and lowest AAR quartiles was
2.15 (95% confidence interval =1.14–4.05). An AAR of 1.53 was identified
as the optimal cutoff. In a prespecified subgroup analysis according to the
time from symptom onset to treatment (>24 vs ≤24 hours), there was no
significant difference in the effect of AAR >1.53 between the two groups.
Conclusion: An increased AAR at admission is significantly
associated with a poor outcome at 3 months in AIS patients.
Keywords: De Ritis ratio, stroke, prognosis,
aspartate transaminase, alanine transaminase, modified Rankin scale, poor
outcome