论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
Authors Dong X, Guo W, Zhang S, Wu T, Sun Z, Yan S, Zheng S
Received 6 April 2017
Accepted for publication 17 June 2017
Published 31 July 2017 Volume 2017:10 Pages 3827—3833
DOI https://doi.org/10.2147/OTT.S139044
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Dr Samir Farghaly
Abstract: Neuropilin-2
(NRP2) is a single-pass transmembrane glycoprotein and has recently been
detected in several human cancer cells. However, its clinical relevance in
hepatocellular carcinoma (HCC) remains unclear. This study aimed at evaluating
NRP2 expression and clinicopathological significance in HCC patients. Tissue microarray
of 190 HCC patients from the First Affiliated Hospital of Zhejiang University
was established, and immunohistochemical staining was performed for NRP2. The
Kaplan–Meier analysis and Cox proportional hazard model were used to analyze
the survival rate. We found that NRP2 expression in HCC was significantly
associated with tumor histological degree (P =0.023) and
cirrhosis (P =0.040). Furthermore,
NRP2-positive HCC patients demonstrated shorter disease-free survival (DFS) and
overall survival (OS) than those of NRP2-negative patients. Then, the
multivariate Cox analysis showed that hazard ratios of NRP2-positive patients
with DFS and OS were 2.167 (95% CI: 1.626, 2.889) and 2.317 (95% CI: 1.548,
3.469), respectively. Our results suggested that NRP2 expression was considered
as an independent factor for the prediction of unfavorable prognosis in HCC
patients, and we believe that NRP2 could serve as a biomarker of poor prognosis
and a novel target in treating HCC tumors.
Keywords: NRP2, hepatocellular carcinoma, unfavorable prognosis,
immunohistochemistry, disease-free survival, overall survival