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Authors Tang C, Xia Z
Received 11 April 2017
Accepted for publication 19 July 2017
Published 11 August 2017 Volume 2017:10 Pages 1899—1904
DOI https://doi.org/10.2147/JPR.S139387
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Minal Joshi
Peer reviewer comments 2
Editor who approved publication: Dr Katherine Hanlon
Abstract: Many nociceptive, inflammatory, and neuropathic pathways contribute to
perioperative pain. Although opioids have long been a mainstay for perioperative
analgesia, other non-opioid therapies, and dexmedetomidine, in particular, have
been increasingly used as part of a multimodal analgesic regimen to provide
improved pain control while minimizing opioid-related side effects. This
article reviews the evidence supporting the preoperative, intraoperative, and
postoperative efficacy of dexmedetomidine as an adjuvant, and the efficacy of
intravenous, spinal canal, and nerve block analgesia with dexmedetomidine for
perioperative acute pain treatment. While there have not been any large-scale
clinical trials conducted, the current body of evidence suggests that
dexmedetomidine is suitable for use as an adjuvant analgesic at all
perioperative stages. However, there are potential adverse effects, such as hypotension
and bradycardia, which must be taken into consideration by clinicians.
Keywords: dexmedetomidine,
analgesia, perioperative pain, non-opioid, adjuvant