已发表论文

在 MRI 引导下,利用还原反应脂质–高分子纳米粒子复合物进行多柔比星 (doxorubicin) 的靶向递送

 

Authors Wu B, Lu S, Deng K, Yu H, Cui C, Zhang Y, Wu M, Zhuo RX, Xu H, Huang S

Received 1 June 2017

Accepted for publication 3 August 2017

Published 14 September 2017 Volume 2017:12 Pages 6871—6882

DOI https://doi.org/10.2147/IJN.S143048

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Professor Murali Yallapu

Peer reviewer comments 3

Editor who approved publication: Dr Linlin Sun

Abstract: In recent years, there has been increasing interest in developing a multifunctional nanoscale platform for cancer monitoring and chemotherapy. However, there is still a big challenge for current clinic contrast agents to improve their poor tumor selectivity and response. Herein, we report a new kind of Gd complex and folate-coated redox-sensitive lipid-polymer hybrid nanoparticle (Gd-FLPNP) for tumor-targeted magnetic resonance imaging and therapy. Gd-FLPNPs can simultaneously accomplish diagnostic imaging, and specific targeting and controlled release of doxorubicin (DOX). They exhibit good monodispersity, excellent size stability, and a well-defined core-shell structure. Paramagnetic nanoparticles based on gadolinium-diethylenetriaminepentaacetic acid-bis-cetylamine have paramagnetic properties with an approximately two-fold enhancement in the longitudinal relaxivity compared to clinical used Magnevist. For targeted and reduction-sensitive drug delivery, Gd-FLPNPs released DOX faster and enhanced cell uptake in vitro, and exhibited better antitumor effect both in vitro and in vivo.
Keywords: redox-sensitive, tumor-targeted, gadolinium, contrast agents, PLGA