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Authors Gao XL, Zhang M, Tang YL, Liang XH
Received 2 May 2017
Accepted for publication 12 July 2017
Published 27 October 2017 Volume 2017:10 Pages 5219—5228
DOI https://doi.org/10.2147/OTT.S140854
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Geoffrey Pietersz
Abstract: More recently, disease metastasis and relapse in many cancer
patients several years (even some decades) after surgical remission are
regarded as tumor dormancy. However, the knowledge of this phenomenon is
cripplingly limited. Substantial quantities of reviews have summarized three
main potential models that can be put forth to explain such process, including
angiogenic dormancy, immunologic dormancy, and cellular dormancy. In this
review, newly uncovered mechanisms governing cancer cell dormancy are
discussed, with an emphasis on the cross talk between dormant cancer cells and
their microenvironments. In addition, potential mechanisms of reactivation of
these dormant cells in certain anatomic sites including lymph nodes and bone
marrow are discussed. Molecular mechanism of cellular dormancy in head and neck
cancer is also involved.
Keywords: cancer cell
dormancy, disseminated tumor cells, head and neck cancer, hypoxia, lymph node
metastasis