德孚在中国

9 0 4 9 6

论文已发表

提 交 论 文


注册即可获取德孚的最新动态

注 册



IF 收录期刊





更多详情 >>





已发表论文

简单的还原敏感胶束用于紫杉醇 (Paclitaxel) 和达沙替尼 (dasatinib) 共同递送以克服肿瘤多药耐药性

 

Authors Li J, Xu R, Lu X, He J, Jin S

Received 3 August 2017

Accepted for publication 14 September 2017

Published 1 November 2017 Volume 2017:12 Pages 8043—8056

DOI https://doi.org/10.2147/IJN.S148273

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 4

Editor who approved publication: Professor Dongwoo Khang

Abstract: Multidrug resistance (MDR) is one of the major obstacles in successful chemotherapy. The combination of chemotherapy drugs and multidrug-resistant reversing agents for treating MDR tumor is a good strategy to overcome MDR. In this work, we prepared the simple redox-responsive micelles based on mPEG-SS-C18 as a co-delivery system to load the paclitaxel (PTX) and dasatinib (DAS) for treatment of MCF-7/ADR cells. The co-loaded micelles had a good dispersity and a spherical shape with a uniform size distribution, and they could quickly disassemble and rapidly release drugs under the reduction environment. Compared with MCF-7 cells, the DAS and PTX co-loaded redox-sensitive micelle (SS-PDNPs) showed stronger cytotoxicity and a more improving intracellular drug concentration than other drug formulations in MCF-7/ADR cells. In summary, the results suggested that the simple co-delivery micelles of PTX and DAS possessed significant potential to overcome drug resistance in cancer therapy.
Keywords: redox responsive, overcoming multidrug resistant, co-delivery, paclitaxel, dasatinib




Download Article[PDF]