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已发表论文
UNBS5162 通过促进细胞凋亡来抑制人视网膜母细胞瘤细胞的增殖
Authors Wang B, Shen J, Wang J
Received 4 July 2017
Accepted for publication 26 September 2017
Published 6 November 2017 Volume 2017:10 Pages 5303—5309
DOI https://doi.org/10.2147/OTT.S145518
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Ashok Kumar Pandurangan
Peer reviewer comments 2
Editor who approved publication: Dr Ingrid Espinoza
Abstract: Human
retinoblastomas are malignant intraocular tumors and have a high incidence in
children. Chemotherapy combined with local therapy is the principal means of
retinoblastoma treatment, the application of which has saved the eye of many
children and avoided external irradiation. UNBS5162, a naphthalimide, has broad
prospects as a tumor treatment, with fewer toxic side effects and higher
cancer-suppression efficiency. However, the efficacy of UNBS5162 in human
retinoblastomas is still not clear. In the present study, we investigated the
specific mechanism of UNBS5162 in the human retinoblastoma cell lines WERIRb1
and Y79. Compared with a negative-control (NC) group, UNBS5162 treatment
for 72 hours significantly decreased cell proliferation; meanwhile, more
apoptotic cells were observed in the UNBS5162-treated group (27.1% in WERIRb1,
20.83% in Y79) than in the NC group (11.59% in WERIRb1, 12.89% in Y79). We also found caspase 3 p17 and Bax expression to be upregulated and Bcl2
downregulated significantly in UNBS5162-treated WERIRb1 and Y79 cells. The
effects of UNBS5162 on human retinoblastoma cells may be regulated by the
Akt–mTOR pathway. We found expression of the Akt pathway and key
proliferation-related genes – those for p-Akt, p-mTOR, p70, and cyclin D1 – were
downregulated significantly in the UNBS5162-treated group compared with the NC
group in WERIRb1 and Y79. Therefore, for the first time, we demonstrated that
UNBS5162 can inhibit proliferation and promote apoptosis of human
retinoblastoma cells by regulating activity of the Akt–mTOR pathway in vitro,
suggesting the potential value of UNBS5162 in treatment for human retinoblastoma.
Keywords: UNBS5162, human retinoblastoma, cell apoptosis, WERIRb1, CXCL
Keywords: UNBS5162, human retinoblastoma, cell apoptosis, WERIRb1, CXCL
