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一种制备简单、载药量高、安全性好的阿霉素—二氯乙酸纳米粒用于肿瘤的治疗
Authors Yang CL, Wu TT, Qin YT, Qi Y, Sun Y, Kong M, Jiang X, Qin XY, Shen YQ, Zhang ZP
Received 17 October 2017
Accepted for publication 18 January 2018
Published 6 March 2018 Volume 2018:13 Pages 1281—1293
DOI https://doi.org/10.2147/IJN.S154361
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Govarthanan Muthusamy
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
摘要：本研究首先合成了一种两亲性的化合物—阿霉素-二氯乙酸，该化合物可借助引入极少量的 PEG 化磷脂实现药物自组装，形成的纳米粒载药量可高达 71.8%，极大地降低了药用辅料引发的安全性问题。该纳米药物具有良好的生物安全性，其体内耐受剂量可达到 75 mg/kg，是常规阿霉素耐受剂量的 15 倍。小鼠黑色素瘤模型评价进一步表明，该纳米药物具有良好的肿瘤靶向性和治疗效果。相关研究为简单高效的纳米药物制备及其临床应用提供了创新性的理论基础和研究思路。
关键词：自组装、阿霉素、药物递送、化疗、纳米药物
