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已发表论文

LEP  和 LEPR  多态性与肝细胞癌风险的关系研究:华东汉族人群病例对照研究

 

Authors Zhang S, Jiang J, Chen Z, Wang Y, Tang W, Liu C, Liu L, Chen Y

Received 12 October 2017

Accepted for publication 16 February 2018

Published 11 April 2018 Volume 2018:11 Pages 2083—2089

DOI https://doi.org/10.2147/OTT.S153931

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Samir Farghaly

Background: Leptin (LEP ) and LEP receptor (LEPR ) polymorphisms may be associated with the development of cancer. 
Methods: In this study, we selected five functional LEP  and LEPR  single-nucleotide polymorphisms (SNPs) and conducted a case–control study to determine the relationship of LEP  and LEPR  polymorphisms with hepatocellular carcinoma (HCC) risk in Eastern Chinese Han population. There were 584 HCC cases and 923 cancer-free controls included in our study. HCC patients and controls were fully matched by age and sex. SNPscan™ genotyping method was used to analyze the genotyping of LEP  rs2167270 G>A, rs7799039 A>G, LEPR  rs6588147 G>A, rs1137100 G>A, and rs1137101 G>A SNPs. 
Results: We found that LEP  rs7799039 A>G and rs2167270 G>A polymorphisms were associated with the susceptibility of HCC in this population (LEP  rs7799039 A>G: GG vs AA: adjusted odds ratio [OR]=2.03, 95% CI, 1.22–3.38, =0.006 and GG vs AA/AG: adjusted OR=1.97, 95% CI, 1.20–3.22, =0.007; rs2167270 G.A: AA vs GG: adjusted OR=2.03, 95% CI, 1.10–3.75, =0.024 and AA vs GG/GA: adjusted OR=2.01, 95% CI, 1.10–3.68, =0.023). However, LEPR  rs6588147 G>A polymorphism decreased the risk of HCC (GA vs GG: adjusted OR=0.62, 95% CI, 0.45–0.86, =0.005 and AA/GA vs GG: adjusted OR=0.64, 95% CI, 0.47–0.88, =0.007). 
Conclusion: This case–control study highlights that LEP  rs7799039 A>G and rs2167270 G>A polymorphisms increase the susceptibility to HCC; however, LEPR  rs6588147 G>A polymorphism may be a protective factor for HCC in Eastern Chinese Han population.
Keywords: LEP, LEPR, polymorphism, hepatocellular carcinoma, risk, single nucleotide polymorphism, hepatitis B virus