论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
Authors Wang Z, Li S, Li Y, Lin N, Huang X, Liu M, Pan WB, Yan XB, Sun LL, Li HY, Li BH, Qu H, Wu Y, Lin P, Ye ZM
Received 20 January 2018
Accepted for publication 17 March 2018
Published 14 May 2018 Volume 2018:10 Pages 1191—1199
DOI https://doi.org/10.2147/CMAR.S163229
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr Antonella D'Anneo
Background: Primary bone sarcomas of the hands or feet are rare lesions and
poorly documented. Moreover, the prognostic determinants of bone sarcomas of
the hands or feet have not been reported.
Materials and
methods: The Surveillance, Epidemiology, and
End Results (SEER) program database was used to screen patients with bone
sarcomas of the hands or feet from 1973 to 2013, with attention paid to
chondrosarcoma, Ewing sarcoma, and osteosarcoma. The prognostic values of
overall survival (OS) and cancer-specific survival (CSS) were assessed using
Cox proportional hazards regression model with univariate and multivariate
analyses. The Kaplan–Meier method was used to obtain OS and CSS curves.
Results: A total of 457 cases were selected from the SEER database.
Chondrosarcoma was the most common form of lesion in hands or feet or both,
followed by Ewing sarcoma and osteosarcoma. The 5- and 10-year OS rates of the
entire group were 75.7% and 66.1%, respectively. The 5- and 10-year CSS rates
were 78.7% and 73.7%, respectively. Multivariate analysis revealed that age
under 40 years, localized stage, low grade, surgical treatment, and first
primary tumor were associated with improved OS, and decade of diagnosis, stage,
grade, and surgery were independent predictors of CSS. However, no significant
differences were observed in OS and CSS among patients with different primary
tumor locations and tumor subtypes. Additionally, the most significant
prognostic factor was whether metastasis had occurred at the time of initial
diagnosis.
Conclusion: Among patients with primary bone sarcomas of the hands or feet,
younger age (<40 years), localized stage, low grade, surgical treatment, and
first primary tumor are favorable factors for prolonging survival.
Keywords: chondrosarcoma, Ewing sarcoma, osteosarcoma, short bone, prognosis