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已发表论文
慢性失眠症患者的半球间功能连接紊乱：一项静息态功能性磁共振成像研究
Authors Zhou F, Zhao Y, Huang M, Zeng X, Wang B, Gong H
Received 12 January 2018
Accepted for publication 28 March 2018
Published 14 May 2018 Volume 2018:14 Pages 1229—1240
DOI https://doi.org/10.2147/NDT.S162325
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Laura D'Antuono
Peer reviewer comments 2
Editor who approved publication: Professor Wai Kwong Tang
Background: Abnormalities
in both cerebral structure and intrinsic activity have been increasingly
reported in patients with chronic insomnia disorder (CID). However, the
interhemispheric integration function in CID is still not well understood.
Functional homotopy reflects an essential aspect of the intrinsic functional
architecture involved in interhemispheric coordination.
Methods: In this study, voxel-mirrored homotopic connectivity (VMHC) was used to analyze the patterns of interhemispheric intrinsic functional connectivity in patients with CID (n=29).
Results: Reduced homotopic connectivity was observed in the middle occipital/posterior middle temporal gyrus in CID patients relative to control subjects. Further analyses demonstrated different insomnia-related heterotopic connectivity patterns in the right and left middle occipital/posterior middle temporal gyrus. Furthermore, within the CID group, the connectivity coefficient within the connectivity network of the middle occipital/posterior middle temporal gyrus was associated with anxiety measures.
Conclusion: Negative significant findings of group differences were found in terms of both the local gray matter density and fractional anisotropy of the white matter skeletal measures in this study; this structural finding, together with the results of VMHC, suggested that disruptions in the intrinsic functional architecture of interhemispheric communication associated with CID can be observed in the absence of detectable microstructural or local morphometric changes in white and gray matter.
Keywords: homotopic connectivity, interhemispheric integration, voxel-mirrored homotopic connectivity, chronic primary insomnia, sleep disorders, resting-state fMRI
Methods: In this study, voxel-mirrored homotopic connectivity (VMHC) was used to analyze the patterns of interhemispheric intrinsic functional connectivity in patients with CID (n=29).
Results: Reduced homotopic connectivity was observed in the middle occipital/posterior middle temporal gyrus in CID patients relative to control subjects. Further analyses demonstrated different insomnia-related heterotopic connectivity patterns in the right and left middle occipital/posterior middle temporal gyrus. Furthermore, within the CID group, the connectivity coefficient within the connectivity network of the middle occipital/posterior middle temporal gyrus was associated with anxiety measures.
Conclusion: Negative significant findings of group differences were found in terms of both the local gray matter density and fractional anisotropy of the white matter skeletal measures in this study; this structural finding, together with the results of VMHC, suggested that disruptions in the intrinsic functional architecture of interhemispheric communication associated with CID can be observed in the absence of detectable microstructural or local morphometric changes in white and gray matter.
Keywords: homotopic connectivity, interhemispheric integration, voxel-mirrored homotopic connectivity, chronic primary insomnia, sleep disorders, resting-state fMRI
