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已发表论文
加载了非诺贝特的介孔二氧化硅纳米粒子口服推挽型渗透泵制剂的开发
Authors Zhao Z, Wu C, Zhao Y, Hao Y, Liu Y, Zhao W
Published Date March 2015 Volume 2015:10 Pages 1691—1701
DOI http://dx.doi.org/10.2147/IJN.S76755
Received 1 November 2014, Accepted 13 December 2014, Published 3 March 2015
Abstract: In this study, mesoporous silica nanoparticles (MSNs) were used to
prepare an oral push–pull osmotic pump. Fenofibrate, the selected model drug,
was firstly loaded into the MSNs, followed by a suspending agent consisting of
a drug layer of push–pull osmotic pump. Fenofibrate-loaded MSNs were
characterized by scanning electron microscopy (SEM), transmission electron
microscopy (TEM), nitrogen adsorption/desorption analysis, differential
scanning calorimetry (DSC), powder X-ray diffractometry (PXRD) analysis, and
Fourier-transform infrared (FT-IR) spectroscopy. Polyethylene oxide of
molecular weight (MW) 100,000 and polyethylene oxide of MW 6,000,000 were
selected as the suspending agent and the expanding agent, respectively.
Cellulose acetate was used as the semipermeable membrane, along with
polyethylene glycol 6,000 to increase the flexibility and control the membrane
permeability. The in vitro dissolution studies indicated that the osmotic pump
tablet combined with MSNs was able to deliver fenofibrate in an approximately
zero-order manner in 24 hours. A pharmacokinetic study showed that, although
the maximum plasma concentration of the osmotic pump was lower than that of the
reference formulation, the relative bioavailability was increased, indicating
that the osmotic pump was more efficient than the reference tablets. Therefore,
using MSNs as a carrier for poorly water-soluble drugs is an effective method
for preparing osmotic pump tablets.
Keywords: poorly water-soluble drug, in vitro dissolution, pharmacokinetic study
Keywords: poorly water-soluble drug, in vitro dissolution, pharmacokinetic study
