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罗氟司特治疗哮喘-慢阻肺重叠的药理机制
Authors Zhang X, Chen Y, Fan L, Ye J, Fan J, Xu X, You D, Liu S, Chen X, Luo P
Received 9 February 2018
Accepted for publication 26 May 2018
Published 1 August 2018 Volume 2018:12 Pages 2371—2379
DOI https://doi.org/10.2147/DDDT.S165161
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Palas Chanda
Peer reviewer comments 3
Editor who approved publication: Professor Manfred Ogris
摘要： 哮喘-慢阻肺重叠（Asthma–COPD
overlap, ACO）是一种不完全阻塞性气道疾病，有着高发病率和死亡率，但是目前对 ACO 并没有明确的定义，也没有有效的干预措施。新发现的磷酸二酯酶-4（PDE-4）抑制剂罗氟司特（Roflumilast）在哮喘、慢性阻塞性肺疾病及 ACO 的治疗中均显示出初步的疗效。然而，罗氟司特的作用机制尚不明了，还没有系统综述对其进行阐释。明确罗氟司特确切的药理机制不仅将指导临床医生用药，还将指导标准化治疗及治疗指南。因此，我们系统总结了罗氟司特治疗 ACO 的药理机制，望为临床应用罗氟司特治疗 ACO 提供参考。
关键词：哮喘-慢阻肺重叠，罗氟司特，磷酸二酯酶-4 抑制剂，机制
