已发表论文

KI-67 阳性细胞指数对巴塞罗那临床肝癌分期 A 期及 B 期肝细胞癌微血管侵犯患者肝切除术预后的影响

 

Authors Li HH, Qi LN, Ma L, Chen ZS, Xiang BD, Li LQ

Received 11 February 2018

Accepted for publication 6 July 2018

Published 10 August 2018 Volume 2018:11 Pages 4747—4754

DOI https://doi.org/10.2147/OTT.S165244

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 3

Editor who approved publication: Dr Samir Farghaly

Objective: This study aimed to explore the relationship between KI-67 positive cellular index and recurrence-free survival (RFS) in Barcelona Clinic Liver Cancer (BCLC) stage A and B hepatocellular carcinoma (HCC) patients, particularly those with microvascular invasion (MVI).
Methods: A total of 333 patients who underwent curative hepatectomy had their immunohistochemistry analyzed retrospectively for KI-67 positive cellular index.
Results: In total, 41.1% (137/333) of HCC patients displayed high KI-67 positive cellular index (>35%). Patients with high KI-67 positive cellular index had poorer RFS than those with low index (<0.0001). Patients were then subdivided into an MVI positivity group (n=192) and an MVI negativity group (n=141). In the MVI positivity group, patients with high KI-67 positive cellular index had a shorter RFS after operation as compared to those with low index (<0.0001). However, there was no significant difference in RFS between high- and low-index subgroups within the MVI negativity group (>0.05). Additionally, patients with high KI-67 positive cellular index combined with MVI positivity had the shortest RFS of all those with MVI negativity, regardless of KI-67 cellular index level (<0.0001). Multivariate analysis showed that node number >1, capsule absence, high KI-67 positive cellular index, and alpha-fetoprotein >400 ng/mL were independent risk factors for a recurrence of HCC with MVI.
Conclusion: Our results suggested that high KI-67 positive cellular index may represent a poor prognostic factor in BCLC stage A and B HCC patients, especially those with MVI.
Keywords: hepatocellular carcinoma, KI-67, microvascular invasion, prognosis, BCLC stage A and B, hepatectomy




Figure 1 Pathologically, primary cellular carcinoma of the liver...