已发表论文

ACE  基因多态性与 COPD 和 COPD 伴肺动脉高压有关:一项综合分析

 

Authors Ma Y, Tong X, Liu Y, Liu S, Xiong H, Fan H

Received 20 March 2018

Accepted for publication 20 May 2018

Published 13 August 2018 Volume 2018:13 Pages 2435—2446

DOI https://doi.org/10.2147/COPD.S168772

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Chunxue Bai

Purpose: Angiotensin-converting enzyme (ACE ) gene I/D polymorphism has been studied in relation to the susceptibility to COPD and COPD with pulmonary hypertension (PH) with inconclusive results. We performed the first comprehensive meta-analysis to evaluate accurately the association between the ACE  gene polymorphism and the risk of COPD.
Methods: Data were analyzed using odds ratios (ORs) and the corresponding 95% CIs to measure the strength of the models. Subgroup analyses were conducted by ethnicity and complication which referred to PH.
Results: In total, 15 studies (2,635 participants) were included in our study, of which four studies (288 participants) were for PH subgroup. The overall analysis results indicated that the ACE  gene polymorphism was not associated with COPD susceptibility in all gene models. However, the ethnic subgroup analysis results indicated that ACE  gene polymorphism was associated with Asians’ susceptibility to COPD (DD+DI vs II, OR=1.47, =0.019, 95% CI: 1.07–2.02). Further, the overall results of the present study detected no statistical significance between ACE  gene polymorphism and the risk of COPD with PH, but the homozygote variant (DD) increased the risk of PH in Asian COPD patients (DD vs ID+II, OR=2.05, =0.05, 95% CI: 1.00–4.19).
Conclusion: The current study suggests that ACE  polymorphism, particularly the homozygote variant (DD), might contribute to the risk of COPD and COPD with PH among Asians. Further studies with larger sample size and more ethnicities are expected to be conducted in the future to validate the results.
Keywords: ACE , COPD, pulmonary hypertension, polymorphism, susceptibility, meta-analysis




Figure 1 The flow diagram of included and excluded studies.