已发表论文

G-CSF 与神经发生有关,可预测胰腺导管腺癌的预后和对化疗的敏感性

 

Authors Zhang L, Tao L, Guo L, Zhan J, Yuan C, Ma Z, Jiang B, Xiu D

Received 10 February 2018

Accepted for publication 28 May 2018

Published 17 August 2018 Volume 2018:10 Pages 2767—2775

DOI https://doi.org/10.2147/CMAR.S165226

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo

Background: Recent studies demonstrated that granulocyte colony-stimulating factor (G-CSF), regularly used for the prevention of neutropenia, is engaged in cancer progression. However, the role of G-CSF in pancreatic ductal adenocarcinoma (PDAC) is not clear. The aim of the present study was to investigate the expression and prognostic value of G-CSF in patients with PDAC.
Materials and methods: The localization and expression of G-CSF in PDAC were examined by immunohistochemistry (IHC). The analysis of the levels of G-CSF in plasma was evaluated using ELISA kit. The correlation between G-CSF expression and patients’ survival was assessed by Kaplan–Meier analysis.
Results: In IHC specimens, G-CSF was discovered predominantly in the cell cytoplasm and expressed in most of PDAC, while in plasma, the systemic level of G-CSF is no different between normal patients and pancreatic cancer patients. In 100 PDAC cases with IHC, patients with grades 2 and 3 were defined as the high expression group (41 patients, 41%), and those with grades 0 and 1 as the low expression group (59 patients, 59%). Significant correlation was noted between high G-CSF expression and neural invasion ( = 0.042) or early recurrence ( < 0.001). G-CSF appeared to be an independent adverse prognostic factor (hazard ratio = 1.774, 95% confidence interval 1.150–2.737, = 0.010) in addition to N stage ( = 0.002). Specifically, adjuvant chemotherapy consisting of gemcitabine prolongs survival of patients with high G-CSF expression (median survival time 14 months vs 7.5 months). Morphologically, high G-CSF expression cells demonstrate the association with neurogenesis.
Conclusion: High expression of G-CSF is a prognostic marker and an indicator to chemotherapy response in PDAC.
Keywords: pancreatic ductal adenocarcinoma, granulocyte colony-stimulating factor, adjuvant chemotherapy, neural invasion, neurogenesis, prognosis




Figure 2 High G-CSF expression cells demonstrate the tendency to surround or...