已发表论文

miR-17-5p 表达对胃肠道癌症的预后价值:系统综述和荟萃分析

 

Authors Wang Z, Zhang J, Zhang Z, Jiang Y, Li M, Li Q, Bai L, Yao D, Wang M, Wang X

Received 21 November 2017

Accepted for publication 20 May 2018

Published 19 September 2018 Volume 2018:11 Pages 5991—5999

DOI https://doi.org/10.2147/OTT.S157670

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 4

Editor who approved publication: Dr Jianmin Xu

Background: There are accumulating studies investigating the aberrant expression of microRNAs in tumor patients. As an important member of miR-17/92 cluster, miR-17-5 p has been identified as a potential prognostic factor for survival in tumor patients. We conducted this meta-analysis aimed to assess the effect of miR-17-5 p as a prognostic biomarker for gastrointestinal tumor patients.
Materials and methods: Eligible studies were enrolled by searching the online databases of PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang Data until September 2017. We calculated pooled hazard ratios (HRs) and 95% CI of miR-17-5 p for overall survival and disease-free survival.
Results: In the categorical variable analysis, we identified 11 studies with 1,279 patients. The pooled analyses suggested that overexpression of miR-17-5 p may predict poor overall survival (HR = 1.86, 95% CI: 1.55–2.25, <0.001) and disease-free survival (HR = 1.43, 95% CI: 1.01–2.03, =0.046) in patients with gastrointestinal tumors. Subgroup analysis showed the pooled HR of overall survival was more significant in tissue specimen, Asian patients, and digestive tract tumors. But there was no correlation between the outcomes and European patients.
Conclusions: This meta-analysis suggested that miR-17-5 p has predictive effects on overall survival and disease-free survival of patients with gastrointestinal tumors.
Keywords: miR-17-5 p, mircoRNA-17-5p, prognosis, survival, meta-analysis




Figure 1 Flow diagram of the study selection process.