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Authors Dang Z, Liu X, Wang X, Li M, Jiang Y, Wang X, Yang Z
Received 23 July 2018
Accepted for publication 2 November 2018
Published 28 December 2018 Volume 2019:13 Pages 221—230
DOI https://doi.org/10.2147/DDDT.S181182
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr Tuo Deng
Abstract: A
systematic review and meta-analysis of previous randomized controlled trials of
traditional Chinese medicine (TCM) supporting Qi and enriching blood in the
treatment of cancer related anemia (CRA) in patients not receiving
chemoradiotherapy were conducted. A total of 13 randomized controlled trials
were included. Compared with the control group, better improvement was found
for the level of hemoglobin (mean difference=4.57, 95% CI [1.38, 7.76], P =0.005) and
overall therapeutic effect (risk ratio [RR]=1.31, 95% CI [1.18, 1.46], P <0.000) in the
TCM groups. The incidence of related adverse events was not increased in the
TCM groups (RR=0.54, 95% CI [0.29, 0.99], P =0.05). However,
due to the relatively low quality and the small sample sizes of the included
studies, the results should be interpreted with a degree of caution. Nevertheless,
TCM with the role of supporting Qi and enriching blood may be a safe and
effective treatment for CRA in patients not receiving chemoradiotherapy and
might be considered as an alternative treatment to conventional western
medicine including iron supplements and erythropoietin.
Keywords: traditional
Chinese medicine, supporting Qi and enriching blood, cancer related anemia,
randomized controlled trial, meta-analysis