论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
Authors Liu YZ, Bi LQ, Chang GL, Guo Y, Sun S
Received 13 August 2018
Accepted for publication 29 November 2018
Published 23 January 2019 Volume 2019:11 Pages 997—1002
DOI https://doi.org/10.2147/CMAR.S183784
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 3
Editor who approved publication: Dr Ahmet Emre Eskazan
Background: Extranodal
natural killer (NK) / T cell lymphoma is a subtype of non-Hodgkin’s lymphoma
(NHL) that usually has an aggressive clinical course. It is the predominant
trigger of lymphoma-associated hemophagocytic syndrome (LAHS), which is highly
lethal and with extremely poor prognosis. This study is aiming to characterize
the associated clinical features and prognostic factors of the disease.
Patients and methods: Twenty-eight
patients with extranodal NK/T cell lymphoma associated hemophagocytic
lymphohistiocytosis (HLH) were retrospectively analyzed. The clinical records
were collected, and the associations between clinical or laboratory parameters
and overall survival (OS) were assessed.
Results: The most
frequently clinical characteristics were fever (96.4%), and splenomegaly
(81.5%). Concerning the laboratory findings, the most common features were
hyperferritinemia (91.7%), grade III/IV thrombocytopenia (64.3%),
hypertriglyceridemia (48%), severe anemia (46.4%), hypofibrinogenemia (45%),
and grade III/IV neutropenia (32.1%). The interval between the diagnosis of
NK/T LAHS and death / last contact was between 4 to 701 days with the median
interval of 15 days. We found that higher serum lactic dehydrogenase (LDH) at
HLH, hypofibrinogenemia, and splenomegaly were significantly associated with
worse survival (P =0.002, 0.003, 0.003). Furthermore, Eastern
Cooperative Oncology Group (ECOG) score, extra-upper aerodigestive tract NK/T
cell lymphoma (EUNKTL) and cutaneous involvement were risk factors of
HLH.
Conclusion: Our data
indicated that levels of LDH, fibrinogen, and presence of splenomegaly were
prognostic factors of the disease. Higher ECOG scores, EUNKTL and cutaneous
involvement were risk factors of NK/T LAHS. Additional independent, prospective
clinical trials will be needed to explore optimal treatment.
Keywords: NK/T-cell
lymphoma, hemophagocytic lymphohistiocytosis, risk factor, prognosis