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用于整形外科植入材料的纳米羟基磷灰石/聚醚生物复合物的制备、特性与在体外成骨细胞中的功能

 

Authors Ma R, Tang SC, Tan HL, Lin WT, Wang YG, Wei J, Zhao LM, Tang TT

Published Date August 2014 Volume 2014:9(1) Pages 3949—3961

DOI http://dx.doi.org/10.2147/IJN.S67358

Received 7 May 2014, Accepted 3 June 2014, Published 18 August 2014

Abstract: A bioactive composite was prepared by incorporating 40 wt% nano-­hydroxyapatite (nHA) into polyetheretherketone (PEEK) through a process of compounding, injection, and molding. The mechanical and surface properties of the nHA/PEEK composite were characterized, and the in vitro osteoblast functions in the composite were investigated. The mechanical properties (elastic modulus and compressive strength) of the nHA/PEEK composite increased significantly, while the tensile strength decreased slightly as compared with PEEK. Further, the addition of nHA into PEEK increased the surface roughness and hydrophilicity of the nHA/PEEK composite. In cell tests, compared with PEEK and ultra-high-molecular-weight polyethylene, it was found that the nHA/PEEK composite could promote the functions of MC3T3-E1 cells, including cell attachment, spreading, proliferation, alkaline phosphatase activity, calcium nodule formation, and expression of osteogenic differentiation-related genes. Incorporation of nHA into PEEK greatly improved the bioperformance of PEEK. The nHA/PEEK composite might be a promising orthopedic implant material.
Keywords: polyetheretherketone, nano-hydroxyapatite, biocomposite, osteoblast functions, orthopedic implant material







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