已发表论文

可控制释放表柔比星的磁性多壁碳纳米管:用于膀胱癌的膀胱内灌注系统

 

Authors Suo N, Wang M, Jin Y, Ding J, Gao X, Sun X, Zhang H, Cui M, Zheng J, Li N, Jin X, Jiang S

Received 4 October 2018

Accepted for publication 4 January 2019

Published 15 February 2019 Volume 2019:14 Pages 1241—1254

DOI https://doi.org/10.2147/IJN.S189688

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Dr Mian Wang

Background: Traditional intravesical instillation treatment in bladder cancer has limited efficacy, which results in a high frequency of recurrence.
Purpose: The aim of this study was to report on an epirubicin (EPI)-loaded magnetic multiwalled carbon nanotube (mMWCNTs-EPI) system for intravesical instillation in place of the current formulation.
Methods: The mMWCNTs-EPI system was formulated with carboxylated MWCNTs, Fe3O4 magnetic nanoparticles, and EPI. Features and antitumor activity of the system were investigated.
Results: Under the effect of external magnets, the mMWCNTs-EPI system showed sustained release and prolonged retention behavior and better antitumor activity than free EPI. The mMWCNTs-EPI system had higher efficiency in enhancing cytotoxicity and inhibiting proliferation in vitro and in vivo than free EPI. Our studies also revealed the atoxic nature of mMWCNTs.
Conclusion: These findings suggested that mMWCNTs are effective intravesical instillation agents with great potential for clinical application.
Keywords: carbon nanotubes, intravesical instillation, epirubicin, intravesical drug delivery




Scheme 1 Schematic illustrations of preparation and use of mMWCNTs-EPI system.