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雷公藤 (Triptolide) 甲素通过抑制核因子 κB 信号通路来减轻大鼠的脑缺血和再灌注损伤

 

Authors Jin XQ, Ye F, Zhang JJ, Zhao Y, Zhou XL

Published Date June 2015 Volume 2015:11 Pages 1395—1403

DOI http://dx.doi.org/10.2147/NDT.S82052

Received 2 February 2015, Accepted 16 March 2015, Published 3 June 2015

Approved for publication by Professor Wai Kwong Tang

Abstract: Inflammation plays critical roles in the acute progression of the pathology of ischemic injury. Previous studies have shown that triptolide interferes with a number of pro-inflammatory mechanisms. In this study, we investigated whether triptolide has protective effects during acute cerebral ischemia/reperfusion (I/R) injury. Male Sprague Dawley rats received triptolide or vehicle at the onset of reperfusion following middle cerebral artery occlusion. Twenty-four hours after reperfusion, we evaluated neurological injuries, the expression of pro-inflammatory markers, and NF-κB activation. I/R rats treated with triptolide showed significantly better neurological deficit scores, decreased neural apoptosis, and reduced cerebral infarct volume and brain edema, and triptolide treatment suppressed the activation of NF-κB following I/R injury. Furthermore, the expression levels of pro-inflammatory cytokines at both the mRNA and protein levels were significantly decreased in rats receiving triptolide. These results indicate that the neuroprotective effects of triptolide during acute cerebral I/R injury are possibly related to the inhibition of both the NF-κB signaling pathway and inflammation.
Keywords: ischemic stroke, inflammation, rat model, NF-κB pathway






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