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已发表论文
高良姜素 (Galangin) 在伴刀豆球蛋白 (Concanavalin A) 诱发的小鼠肝炎中的保护作用
Authors Luo Q, Zhu L, Ding J, Zhuang X, Xu L, Chen F
Published Date June 2015 Volume 2015:9 Pages 2983—2992
DOI http://dx.doi.org/10.2147/DDDT.S80979
Received 15 January 2015, Accepted 14 April 2015, Published 10 June 2015
Approved for publication by Prof. Dr. Shu-Feng Zhou
Abstract: Galangin is an active pharmacological ingredient from propolis and Alpinia officinarum Hance , and has been reported to have anti-inflammatory and antioxidative properties. The present study aims to reveal the effect of galangin on Concanavalin A (ConA)-induced hepatitis (CIH), a well-established animal model of immune-mediated liver injury, and to clarify the related mechanism. C57BL/6 mice were pretreated with galangin followed by ConA challenge. Results indicated that galangin inhibited ConA-induced liver damage. Mice pretreated with galangin showed more reduction of liver damage when compared with control mice pretreated with vehicle solution. In galangin-pretreated mice with induced CIH, increases in serum levels of several inflammatory cytokines, including tumor necrosis factor-α, interferon-γ, and interleukin-12 were dramatically attenuated, and chemokines and adhesion molecules like interferon inducible protein-10, macrophage inflammatory protein-1α, and intercellular adhesion molecule-1 messenger RNA expressions in liver were decreased. Moreover, CIH mice pretreated with galangin showed less leukocyte infiltration and T-cell activation in the liver. Further, the mechanism of the anti-inflammatory effects of galangin may be attributed to its modulation of crucial inflammatory signaling pathways, including nuclear factor kappa B and interferon-gamma/signal transducer and activator of transcription 1. Collectively, these findings suggest the preventive and therapeutic potential of galangin in immune-mediated liver injury in vivo.
Keywords: galangin, Concanavalin A-induced hepatitis, nuclear factor kappa B, STAT1
Keywords: galangin, Concanavalin A-induced hepatitis, nuclear factor kappa B, STAT1
