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Authors Lei L, Ye W, Zheng L, Huang P, Shi L, Huang J, Zheng Y, Chen Z, Wang X, Wang X
Received 30 December 2018
Accepted for publication 26 February 2019
Published 17 April 2019 Volume 2019:12 Pages 2931—2936
DOI https://doi.org/10.2147/OTT.S199931
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Ms Aruna Narula
Peer reviewer comments 2
Editor who approved publication: Dr Federico Perche
Abstract: Metastatic
breast cancer (MBC) is the most life-threatening disease in women worldwide. HER2-mutated
breast carcinoma has been reported to benefit from HER2-targeted tyrosine
kinase inhibitors recently. Here, we presented a heavy pretreated and harbored
HER2 V777L mutation de novo stage IV Luminal B (HER2 unamplified) breast cancer
patient who achieved an unexpected good response to trastuzumab combined with
vinorelbine therapy. Although HER2-unamplified MBC patients do not regularly
benefit from anti-HER2 target therapy, HER2 V777L mutation detected by
next-generation sequencing from ctDNA may present as a predictive biomarker for
anti-HER2-based strategy therapy in HER2-negative MBC patients.
Keywords: metastatic
breast cancer, HER2 gene mutation, trastuzumab