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Authors Zhou X, Sun X, Zhao W, Fang X, Wang X
Received 4 November 2018
Accepted for publication 14 February 2019
Published 7 May 2019 Volume 2019:11 Pages 4243—4254
DOI https://doi.org/10.2147/CMAR.S193397
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Professor Lu-Zhe Sun
Background: Accumulating
evidence suggested that tumor microenvironment and host immune system played
important roles in determining the clinical course and outcome of human
malignancies. The derived neutrophil to lymphocyte ratio (dNLR) and absolute
lymphocyte count (ALC) were demonstrated to act as a prognostic factor in
several malignancies. Nevertheless, the prognostic significance of them in
extranodal natural killer/T-cell lymphoma (ENKTL) patients has never been
explored.
Patients and methods: A total
of 33 newly diagnosed patients with ENKTL were included in this study.
Clinicopathological characteristics were collected and prognostic significance
of dNLR and ALC were evaluated.
Results: Elevated
dNLR and low ALC were both associated with poor survival rates. Patients with
dNLR ≥3.6 revealed significantly shorter overall survival (OS) (P=0.001) and
progression-free survival (PFS) (P=0.008) than those with dNLR 9,/L had worse OS (P =0.008) and PFS (P <0.001) than
those with ALC ≥0.8×109/L. An independent significant association
between low ALC and poor clinical outcome in multivariate analysis for OS (HR,
36.023; 95% CI, 2.438–532.243; P =0.009) as well as PFS (HR, 7.698; 95%CI,
1.573–37.679; P =0.012) was identified.
Conclusion: In this
study, we validated for the first time the prognostic value of dNLR and ALC in
ENKTL patients. Elevated dNLR and low ALC were both associated with aggressive
tumor process and poor survival.ALC value at diagnosis represented an
independent favorable prognostic factor for the clinical outcome of ENKTL
patients.
Keywords: derived
neutrophil to lymphocyte ratio, absolute lymphocyte count, extranodal NK/T-cell
lymphoma, prognosis, progression-free survival, overall survival