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用于药物和基因传递的刺激响应性囊泡聚合物纳米融合剂
Authors Mu X, Gan S, Wang Y, Li H, Zhou G
Received 30 January 2019
Accepted for publication 8 May 2019
Published 18 July 2019 Volume 2019:14 Pages 5415—5434
DOI https://doi.org/10.2147/IJN.S203555
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Melinda Thomas
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Abstract: Over the past two decades, nano-sized biosystems have increasingly been utilized to deliver various pharmaceutical agents to a specific region, organ or tissue for controllable precision therapy. Whether solid nanohydrogel, nanosphere, nanoparticle, nanosheet, micelles and lipoproteins, or “hollow” nanobubble, liposome, nanocapsule, and nanovesicle, all of them can exhibit outstanding loading and releasing capability as a drug vehicle – in particular polymeric nanovesicle, a microscopic hollow sphere that encloses a water core with a thin polymer membrane. Besides excellent stability, toughness and liposome-like compatibility, polymeric nanovesicles offer considerable scope for tailoring properties by changing their chemical structure, block lengths, stimulus-responsiveness and even conjugation with biomolecules. In this review, we summarize the latest advances in stimulus-responsive polymeric nanovesicles for biomedical applications. Different functionalized polymers are in development to construct more complex multiple responsive nanovesicles in delivery systems, medical imaging, biosensors and so on.
Keywords: nanovesicle, stimulus-responsive, amphiphilic block copolymer, self-assembled, drug delivery