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UHRF1 蛋白复合体在恶性肿瘤中的表观遗传学作用及靶向治疗
Authors Xue B, Zhao J, Feng P, Xing J, Wu H, Li Y
Received 25 October 2018
Accepted for publication 10 December 2018
Published 11 January 2019 Volume 2019:12 Pages 549—559
DOI https://doi.org/10.2147/OTT.S192234
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr Sanjeev Srivastava
摘要：泛素样含 PHD 和环指域蛋白-1（UHRF1）作为表观调节蛋白，通过不同结构域募集 PCNA，DNMT1，HDAC1，G9a，SuV39H，HAUSP 和 Tip60 等蛋白至对应的 DNA 和组蛋白来维持 DNA 甲基化和组蛋白修饰。UHRF1 正日益被认为是多种肿瘤的标记物，参与其 DNA 的高甲基化和整体基因组低甲基化，参与肿瘤的发生，恶化及侵袭等过程。该篇综述主要阐述 UHRF1 作为 DNA 甲基化和组蛋白修饰的适配器作用，其蛋白复合体在表观遗传学中的动态调节机制，修饰及靶向性药物的研究进展。
Keywords: UHRF1
protein complex, epigenetic modification, ICBP90
摘要视频链接：Role of UHRFIin
cancer therapies
