Abstract: We present here the first report of an OXA-181-producing Klebsiella pneumoniae  isolated from the fecal specimen of a patient in China. The OXA-181-encoding gene bla _OXA-181 was located on a 51 kb IncX3-type plasmid. Conjugation assay and whole-genome sequencing analysis revealed that this transferrable plasmid in the K. pneumoniae  isolate might have originated from Escherichia coli and have the potential to mediate the spread of bla _OXA-181.
Keywords: OXA-181, Klebsiella pneumoniae , IncX3 plasmid, China, human