Novel coronavirus disease (COVID-19) pandemic is becoming a threat of global public health. Up to Aug 31, 2020, 182 countries and territories have reported a cumulative total of 24,854,140 COVID-19 cases; 838,924 of them have died (https://www.who.int/ emergencies/diseases/novel-coronavirus-2019/situation-reports). Recent data noticed that SARS-CoV-2 RNA test results of the recovered COVID-19 patients returned positive, termed “re-positive” phenomenon.1,2 However, the clinical characteristics and the immune biomarkers of “re-positive” COVID-19 patients are still far from being fully understood. We therefore conducted this retrospective study to clarify the clinical features and possible risk predictors of “re-positive” in discharged COVID-19 patients.