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了解多氯联苯对脂质代谢的多重影响
Authors Shan Q, Li H, Chen N, Qu F, Guo J
Received 24 June 2020
Accepted for publication 19 August 2020
Published 13 October 2020 Volume 2020:13 Pages 3691—3702
DOI https://doi.org/10.2147/DMSO.S264851
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Juei-Tang Cheng
摘要：多氯联苯是一种典型的环境污染物，近年来多项研究表明多氯联苯暴露能够破坏新陈代谢。脂质作为一种高度复杂的生物分子，不仅是构成生物膜结构的基础，还是信号分子和能源来源。脂质代谢紊乱可诱发多种疾病，如糖尿病、脂肪肝和代谢综合征等。虽然目前文献已经报道了多氯联苯可以影响脂质的合成、摄取和分解等一系列脂质代谢途径，但鲜有文章系统性地总结出多氯联苯暴露引起的脂质代谢紊乱的详细过程。多种分子参与脂质代谢调控过程，然而目前关于多氯联苯暴露的敏感关键因子尚未完全阐明。因此，在这篇文章中，我们对环境中暴露的多氯联苯暴露与其相关脂质代谢紊乱的生物标志物最新研究进展进行了总结。
Keywords: PCBs, metabolism-disrupting chemicals, hepatocytes, lipid metabolism