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妊娠期糖尿病实验性动物模型的研究进展
Authors He Y, Wu N, Yu W, Li L, OuYang H, Liu X, Qian M, Al-Mureish A
Received 17 July 2020
Accepted for publication 5 October 2020
Published 9 November 2020 Volume 2020:13 Pages 4235—4247
DOI https://doi.org/10.2147/DMSO.S270935
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Konstantinos Tziomalos
摘要：妊娠期糖尿病（Gestational Diabetes Mellitus，GDM）是指妊娠期间发生的不同程度的糖代谢异常，但血糖未达到显性糖尿病的水平，占妊娠合并高血糖状态的80%-90%。妊娠期间的血糖增高，密切影响着妊娠过程，经常导致一系列母体不良结局，对子代未来产生深远影响。建立合适的 GDM 模型是研究 GDM 发病机制、选择合理药物、观察疾病走向和结局的基础，目前国内外研究中，实验性 GDM 动物模型的建立方法和动物选择多种多样，本文就目前研究中已经建立的各种 GDM 模型及其诱导方法进行综述。
Keywords: gestational diabetes mellitus, animal model, chemical induction, high-sugar and high-fat diet, genetic manipulation