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Purpose: Recent studies have identified important roles for long intergenic non-protein coding RNA 1426  (LINC01426 ) in glioma and clear cell renal cell carcinoma. The present study evaluated the expression profile of LINC01426  in non-small cell lung cancer (NSCLC) tissues and cell lines. Furthermore, the function of LINC01426  in NSCLC and the molecular mechanisms involved were extensively studied.
Methods: The abundance of LINC01426  in NSCLC tissues and cell lines was determined using quantitative reverse transcription–polymerase chain reaction. The cell counting kit-8 assay, flow cytometry, transwell experiments for migration and invasion, and xenograft tumor model were used to assess the function of LINC01426  in NSCLC cells. Mechanistic studies were performed using the luciferase reporter assay and RNA immunoprecipitation.
Results: Significant LINC01426  upregulation was observed in NSCLC tissues and cell lines. Silencing LINC01426  inhibited proliferation, migration, and invasion of NSCLC cells and facilitated cell apoptosis in vitro. Furthermore, interference of LINC01426  restricted tumor growth of NSCLC cells in vivo. In addition, LINC01426  showed the ability to directly bind to microRNA-519d-5p (miR-519d-5p) and act as a molecular sponge for miR-519d-5p in NSCLC cells. Furthermore, the ETS proto-oncogene 1  (ETS1 ) was identified as a direct target of miR-519d-5p and LINC01426  could indirectly upregulate ETS1  expression by sponging miR-519d-5p. Moreover, the cancer-inhibiting activities of LINC01426  knockdown in NSCLC cells were partially offset by miR-519d-5p inhibition.
Conclusion: LINC01426  increases ETS1  expression by sequestering miR-519d-5p, thereby aggravating the malignant progression of NSCLC. The LINC01426/miR-519d-5p/ETS1 competing endogenous RNA pathway may provide a target for designing therapeutic agents for NSCLC treatment.
Keywords: long intergenic non-protein coding RNA 1426, NSCLC, ETS proto-oncogene 1, ceRNA