Purpose: Gastric cancer (GC) is a type of malignant cancer with a poor prognosis. The iron’s metabolism plays an important role in the process of GC. The aim of this study was to evaluate the effectiveness of SLC22A17 , associated with iron metabolism, in predicting the prognosis of GC patients.
Materials and Methods: We analyzed genes related to iron metabolism of gastric cancer mRNA-seq data from TCGA database. We identified an iron metabolism-related SLC22A17  as an independent prognostic factor using univariate and multivariate Cox regression analysis.
Results: Further research showed that SLC22A17  was related with many pathways involved in the process of gastric cancer, and the expression was associated with diverse cancer-infiltrating immune cells. The expression of SLC22A17  was associated with T (Topography).
Conclusion: We validated that SLC22A17  associated with iron metabolism could serve as a prognostic biomarker for GC patients.
Keywords: gastric cancer, iron metabolism, SLC22A17 , prognostic marker