Background: Many inflammation-related gene polymorphisms are associated with susceptibility to recurrent miscarriage. SERPINA4  is involved in inflammation and is associated with susceptibility to a variety of diseases, but its relevance in recurrent miscarriage is unclear. Therefore, this study aimed to investigate the relationship between SERPINA4  gene polymorphisms and susceptibility to recurrent spontaneous abortion.
Methods: Two SERPINA4  polymorphisms were genotyped in 631 patients with recurrent miscarriage and 771 controls by TaqMan real-time polymerase chain reaction, and the strength of each association was evaluated through 95% confidence intervals (CIs) and odds ratios (ORs).
Results: The results showed that SERPINA4  rs2070777 AA genotypes were associated with an increased risk of recurrent miscarriage (AA vs AT/TT adjusted OR=1.409, 95% CI=1.032– 1.924, P=0.0309), and we also found a significant association between the rs910352 T allele in the SERPINA4  gene and susceptibility to recurrent miscarriage (CT vs CC adjusted OR=1.579, 95% CI=1.252– 1.992, P=0.0001; TT vs CC adjusted OR=1.524, 95% CI=1.134– 2.049, P=0.0052). The combined analysis of two SNPs of the SERPINA4  gene revealed that carriers with one to two unfavorable genotypes were associated with a higher risk for recurrent miscarriage compared with individuals with no unfavorable genotypes (adjusted OR=1.257, 95% CI=1.019-1.550). Moreover, our study indicates that having one to two unfavorable genotypes is associated with an increased risk of recurrent miscarriage in women 35– 40 years of age.
Conclusion: Our study suggests that SERPINA4  rs2070777AA genotypes might contribute to an increased risk of recurrent miscarriage in a southern Chinese population.
Keywords: recurrent miscarriage, SERPINA4 , genetic susceptibility, polymorphism