Purpose: This study aimed to investigate the role of chemokine receptor 2 (CXCR2 ) gene polymorphisms in peri-implantitis susceptibility in a Chinese Han population.
Patients and Methods: A total of 260 individuals were included in this study, including 127 peri-implantitis patients and 133 healthy implants. CXCR2  gene rs2230054 and rs1126580 polymorphisms in different groups were analyzed by the Chi-square test. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were employed to evaluate the association between CXCR2  polymorphism and peri-implantitis susceptibility.
Results: The CT genotype of rs2230054 and the AG genotype and G allele of rs1126580 significantly increased in peri-implantitis patients compared with healthy implants (P < 0.05). The CT genotype of rs2230054 (OR = 1.825, 95% CI = 1.028– 3.239) and the AG genotype of rs1126580 (OR = 2.223, 95% CI 1.272– 3.885) carriers had a high risk to infect with peri-implantitis. Additionally, these CXCR2  gene polymorphisms have been revealed to be associated with the periodontal status of peri-implantitis patients.
Conclusion: The CXCR2 gene rs2230054 and rs1126580 polymorphisms were associated with the peri-implantitis susceptibility in the Chinese Han population. The CT genotype of rs2230054 and the AG genotype and G allele of rs1126580 serve as risk factors for the occurrence of peri-implantitis.
Keywords: chemokine receptor 2, CXCR2 , polymorphism, peri-implantitis, Han population