Purpose: This study aimed to evaluate the associations between mitochondrial dynamics related genes -MFN1, MFN2  and DRP1  polymorphisms and risk of lung cancer.
Methods: Six polymorphisms of MFN1, MFN2  and DRP1  were genotyped in 600 cases and 600 controls using a MassARRAY platform.
Results: The MFN1  rs13098637-C and DRP1  rs879255689-A alleles were associated with an increased risk of lung cancer (p _rs13098637=0.004, p _rs879255689=0.005), while MFN2  rs4240897-A and rs2236058-G were related to a decreased risk of disease (p < 0.001). The rs13098637-TC/CC and rs879255689-GA/AA were determined as risk genotypes for lung cancer (p _rs13098637=0.014, p _rs879255689=0.013), whereas the rs4240897-GA/AA and rs2236058-GG were identified as protective genotypes against lung cancer risk (p < 0.001). Genetic model analysis showed that rs13098637 was correlated with an elevated risk of lung cancer in dominant and log-additive models (p _dominant=0.007, p _log-additive=0.004). Moreover, rs879255689 was associated with an increased risk of disease in all three models (p _dominant=0.014, p _recessive=0.028, p _log-additive=0.005). In contrast, rs4240897 and rs2236058 were related to reduced risk of disease in all three models (rs4240897: p _all< 0.001; rs2236058: p _dominant=0.008, p _recessive< 0.001, p _log-additive< 0.001). In addition, these associations were related to the smoking status and pathological type of lung cancer patients.
Conclusion: These results shed new light on the association between mitochondrial dynamics related genes and risk of lung cancer.
Keywords: lung cancer, gene polymorphisms, mitochondrial dynamics, MFN1, MFN2