Objective: The aim of this study was to investigate the correlations between molybdenum target X-ray mammography features and the expressions of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in invasive breast cancer (IBC) and their clinical significance.
Methods: The correlations between the mammographic features and expressions of ER, PR, and HER2 in 378 cases of IBC confirmed by pathology were analyzed retrospectively.
Results: The differences in the ER, PR, and HER2 positive expression between gland types were statistically significant (P < 0.05). The expression of ER was positively correlated with the presence of nipple depression (P < 0.05). Moreover, ER and PR expressions were positively correlated with the absence of axillary lymph node enlargement (P < 0.05) and negatively correlated with the maximum tumor diameter (P < 0.05).
Conclusion: The mammographic features of IBC are correlated with the expression of immunity indices ER, PR, and HER2 and reflect several pathological features.
Keywords: invasive breast cancer, molybdenum target X-ray mammography, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2