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天然聚合物壳聚糖，酰胺类局麻药的一种优秀缓释载体
Authors Yu YM, Long YZ, Zhu ZQ
Received 27 July 2024
Accepted for publication 18 October 2024
Published 30 October 2024 Volume 2024:17 Pages 3539—3551
DOI https://doi.org/10.2147/JPR.S480926
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Karina Gritsenko
摘要：局麻药，尤其是酰胺类局麻药，在围术期麻醉镇痛和长期慢性疼痛控制上运用广泛，而局麻药的作用时效短，一直都是大家竭力想解决的问题。简单给药，可提供局麻药长效作用的缓释材料研发一直被寄予厚望。其中，壳聚糖因为其良好的生物相容性、可降解性、成本低和具备同酰胺类局麻药亲和的氨基结构等优势，被用于酰胺类局麻药缓释。本文拟通过梳理现有的壳聚糖缓释材料用于酰胺类局麻药缓释的使用情况，总结相关研究进展，进而探讨其医疗应用的可行性和应用潜力。