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载脂蛋白E基因和epsiv；4等位基因与多血管床动脉粥样硬化相关
Authors Lin Y, Yang M, Liu Q, Cai Y, Zhang Z, Xu C, Luo M
Received 25 August 2024
Accepted for publication 26 October 2024
Published 3 November 2024 Volume 2024:17 Pages 5039—5048
DOI https://doi.org/10.2147/IJGM.S475771
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Redoy Ranjan
Youni Lin, Min Yang, Qifeng Liu, Yufu Cai, Zhouhua Zhang, Chongfei Xu, Ming Luo
Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou, People’s Republic of China
Correspondence: Youni Lin, Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou, People’s Republic of China, Email linyn2024@126.com
Background: Atherosclerosis is a systemic disease that can involve multiple vascular beds. The risk factors for atherosclerosis in multiple vascular beds remain unclear. Apolipoprotein E (APOE) is involved in inflammation and lipid deposition in the process of atherosclerosis. The objective of this study was to investigate whether APOE polymorphisms are associated with atherosclerosis in multiple vascular beds.
Methods: A total of 416 patients with atherosclerosis in single vascular bed and 658 patients with atherosclerosis in multiple vascular beds were included. APOE genotypes were detected and the differences of APOE genotypes between the groups were compared. Logistic regression analysis was performed to analyze the relationship between APOE genotypes and atherosclerosis in multiple vascular beds.
Results: APOE E3/E4 genotype frequency was lower in the patients with atherosclerosis in multiple vascular beds than that of patients with atherosclerosis in single vascular bed (11.4% vs 17.8%, P=0.004). There was no significant difference in age and gender distribution, proportion of history of smoking, alcohol consumption, hypertension, and diabetes mellitus between the two groups (all P> 0.05), and among patients with different APOE alleles (all P> 0.05). Logistic regression analysis indicated that APOE E3/E4 genotype (E3/E4 vs E3/E3: odds ratio (OR) 0.598, 95% confidence interval (CI): 0.419– 0.854, P=0.005), and APOE ϵ4 allele (ϵ4 vs ϵ3: OR 0.630, 95% CI: 0.444– 0.895, P=0.010) associated with atherosclerosis in multiple vascular beds.
Conclusion: APOE ϵ4 allele is associated with atherosclerosis in multiple vascular beds.
Keywords: APOE, polymorphism, atherosclerosis, multiple vascular beds