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已发表论文
机械信号转导：流体剪切力在骨关节炎发展中的关键作用
Received 1 October 2024
Accepted for publication 10 November 2024
Published 3 December 2024 Volume 2024:17 Pages 10199—10207
DOI https://doi.org/10.2147/JIR.S498914
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Adam D Bachstetter
摘要
在全球范围内，骨关节炎是一种常见的高度致残性疾病，给社会和医疗系统带来沉重负担。生物力学因素在骨关节炎发生发展中的作用逐渐受到重视。流体剪切力作为一种关键的生物力学刺激，因其在维持软骨健康和疾病进展中的双重作用而成为研究的焦点。本文深入探讨了流体剪切力在骨关节炎中的机制及其对疾病过程的影响，旨在揭示流体剪切力如何通过调控软骨细胞的生理功能和信号转导通路影响骨关节炎的发生发展。