Mingxing Yan, Jinji Wang, Liying Li

Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, 350000, People’s Republic of China

Correspondence: Liying Li, Fujian Maternity and Child Health Hospital, Fujian Medical University, 18 Daoshan Road, Gulou District, Fuzhou, 350000, People’s Republic of China, Tel +86-0591-87279624, Email liyingl1225@163.com

Objective: To investigate the correlation between uric acid (UA), urinary protein (UP) and umbilical artery blood flow related parameters and maternal and infant prognosis in patients with hypertensive disorder complicating pregnancy (HDP).
Methods: A total of 110 hDP patients who underwent prenatal examination and delivered in our hospital from June 2018 to May 2023 were selected as the HDP group. According to the prognosis of mother and infant, they were divided into normal prognosis group (n=80) and poor prognosis group (n=30). In addition, 110 healthy pregnant women who received prenatal examination in the same hospital during the same period were randomly selected as healthy control group. The maternal and infant outcomes, UA, 24-h-UP level, umbilical artery blood flow pulsation index (PI), resistance index (RI) and systolic and diastolic blood flow velocity ratio (S/D) were compared between the two groups. Logistic regression analysis was used to analyze the factors related to the above probability and maternal and infant prognosis.
Results: The total incidence of adverse maternal and infants outcome in the HDP group was higher than that of HC (37.5% VS16.65%) (P < 0.05). The HDP group UA, 24-h-UP and PI, RI, and S / D higher than HC (P < 0.05). Logistic regression analysis shows that the age of pregnant women and 24-h-UP, PI, RI, S / D are related factors that affect the prognosis of adverse maternal and infants outcome (P < 0.05).
Conclusion: The UA and UP levels and umbilical artery blood flow-related parameters in HDP patients were significantly increased. Maternal age and 24-h-UP, RI, and S/D are all relevant factors that affect the adverse maternal and fetal prognosis of HDP patients.

Keywords: uric acid, urinary protein, umbilical artery blood flow, pregnancy-induced hypertension