Shi Yin,1,* Xiyan Zhao,2,* Tian Li,3,* Xingxuan Li,1 Zongjun Xie,1 Hao Tang,1 Yi Wang,1 Zhiwei Jia,1 Tianlin Wen,1 Yaohong Wu4 

1Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 3Outpatient Department of the Ministry of Foreign Affairs, Beijing, People’s Republic of China; 4Department of Spine Surgery, Ganzhou People’s Hospital, Ganzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Zhiwei Jia; Yaohong Wu, Email jiazhiweivip@163.com; wuyaohong1986@126.com

Purpose: The debate over the effectiveness of platelet-rich plasma (PRP) versus hyaluronic acid (HA) in treating hip osteoarthritis (HOA) continues. This cross-sectional analysis of overlapping systematic reviews aims to evaluate the efficacy of intra-articular PRP compared to HA for HOA treatment. The goal is to guide decision-makers in selecting the most reliable systematic reviews and to provide treatment recommendations based on the best available evidence.
Methods: We conducted comprehensive searches of PubMed, EMBASE, and Cochrane Library databases to identify systematic reviews comparing intra-articular PRP and HA for HOA treatment. The methodological quality of these reviews was assessed, and relevant data were extracted. The Jadad algorithm was applied to determine which reviews provided the most robust evidence.
Results: Five systematic reviews were included, all categorized as Level-II evidence. The Assessment of Multiple Systematic Reviews scores ranged from 4 to 9, with a median score of 8. A high-quality systematic review was chosen according to the Jadad algorithm. It is suggested that there were no significant differences observed in the improvement of any short-term outcome scores (mean follow-up of 12.2 months for PRP, 11.9 months for HA), including the Western Ontario and McMaster Universities Osteoarthritis Index, the Visual Analog Scale for pain, and the Harris Hip Score, from pre-injection to post-injection between the groups.
Conclusion: There is inconsistency among the conclusions of the overlapping systematic reviews comparing intra-articular PRP and HA for HOA treatment. The best evidence indicates that PRP and HA injections yield similar short-term clinical benefits for patients with HOA. Further studies with larger sample sizes and longer follow-up periods are needed to provide more definitive conclusions.

Keywords: platelet-rich plasma, hyaluronic acid, Hip osteoarthritis, systematic review