Yufang Wang, Xiangrong Zhao

Department of Radiotherapy, Liaocheng Hospital Affiliated to Shandong First Medical University (Liaocheng People’s Hospital), Liaocheng, Shandong, People’s Republic of China

Correspondence: Xiangrong Zhao, Email zxrzai@163.com

Introduction: Superior orbital fissure syndrome (SOFS) is a rare condition that involves damage to multiple structures within the superior orbital fissure, often caused by trauma, inflammation, or tumors. Lung adenocarcinoma, known for its propensity to metastasize, can lead to orbital metastases, which can manifest as SOFS. This case underscores the diagnostic and therapeutic challenges associated with such rare metastatic presentations.
Case Presentation: A 60-year-old woman with a history of left lung adenocarcinoma presented with left eyelid ptosis and fixed eye position following hair dyeing. Despite initial treatments and imaging, her condition persisted. Subsequent imaging and thorough clinical evaluation revealed metastasis to the left superior orbital fissure. The patient was treated with volumetric modulated arc therapy (VMAT), leading to significant clinical improvement and reduction of the orbital mass.
Conclusion: This case highlights the critical role of comprehensive diagnostic evaluation and communication between specialists in managing rare metastatic conditions. It also demonstrates the efficacy of localized radiotherapy in treating such uncommon presentations of lung cancer metastasis.

Keywords: superior orbital fissure syndrome, lung adenocarcinoma, metastasis, radiotherapy, case report