Yuzhan Chen,1,2 Ying Chen,3 Yimin He,4 Qitian Mu,3 Guifang Ouyang1 

1Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, People’s Republic of China; 2Health Science Center, Ningbo University, Ningbo, 315000, People’s Republic of China; 3Laboratory of Stem Cell Transplantation, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, People’s Republic of China; 4Department of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, People’s Republic of China

Correspondence: Guifang Ouyang, Department of Hematology The First Affiliated Hospital of Ningbo University, Ningbo, 315000, People’s Republic of China, Email fyyouyangguifang@nbu.edu.cn

Abstract: Post-transplant lymphoproliferative disorder (PTLD) is a rare complication following hematopoietic stem cell transplantation (HSCT), with its occurrence post-autologous hematopoietic stem cell transplantation (auto-HSCT) being even rarer. Research on PTLD following auto-HSCT is exceedingly scarce. Here, we present a noteworthy instance wherein a patient with diffuse large B-cell lymphoma (DLBCL) developed PTLD, manifesting as classical Hodgkin lymphoma (cHL) two years after auto-HSCT. Additionally, we conducted an extensive review of existing literature, exploring the current research on PTLD following auto-HSCT and illuminating this scarcely examined area.

Keywords: post-transplant lymphoproliferative disorder, Hodgkin’s lymphoma, diffuse large B-cell lymphoma, Epstein-Barr virus