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术前口服塞来昔布可降低老年股骨颈骨折患者谵妄风险，有利于功能恢复：倾向评分匹配分析
Authors Ju M, Han X, He L, Jiang J, Wang M, Lin W, Liu Y
Received 14 December 2024
Accepted for publication 6 February 2025
Published 15 February 2025 Volume 2025:18 Pages 709—717
DOI https://doi.org/10.2147/JPR.S507116
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Karina Gritsenko
Minyan Ju,1 Xiaofei Han,2 Li He,1 Jingjing Jiang,1 Mengmeng Wang,1 Wenting Lin,1 Yuan Liu1
1Orthopaedics Department, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; 2Orthopaedics Department, Wuxi No. 9 People’s Hospital, Wuxi, Jiangsu, People’s Republic of China
Correspondence: Yuan Liu, Orthopaedics Department, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 0700014, People’s Republic of China, Email liuyuan_81811@163.com
Background: We aim to explore whether the effect of oral celecoxib (OC) preoperatively in elderly patients with femoral neck fracture (FNF) receiving surgery on the pain control, complications, functional outcomes, and mortality.
Methods: We collected data on elderly patients with FNF in two hospitals between Jan. 2020 and May. 2024. According to OC use or not, patients were divided into OC group and non-OC group. We performed propensity score matching (PSM) analysis to minimize potential confounding and selection bias. We observed the factors that may influence pain control by Spearman correlations.
Results: Finally, 908 patients met our inclusion criteria, including 494 patients in the OC group and 414 in non-OC patients. We found that many factors, such as age, body mass index, and fracture type, were significantly different. Thus, we used PSM analysis to lower potential confounding, and 215 patients remained in each group. The results showed that VAS scores at the time of 1st day after surgery, 3rd day after surgery and at discharge were markedly lower in OC group. Additionally, lower delirium rate and better functional outcomes were found in OC group. Our finding showed no significant difference in mortality rates at 30-day, 90-day, and 12-month between two groups.
Conclusion: Preoperative OC can manage pain control, have better functional recovery, and minimize pain-related complications such as delirium in elderly patients with femoral neck fracture.
Level of Evidence: Level III.
Keywords: celecoxib, elderly, femoral neck fracture, pain, delirium